Proteasomes
How proteasomes are work(explain about proteasomes)
- They are involved in cellular differentiation (where they degrade transcription factors and metabolic enzymes
- As part of the Ub system, they are involved in regulating the cell cycle1. They remove abnormal and misfolded proteins from the cell.
- They remove abnormal and misfolded proteins from the cell.
- They are involved in the cell's stress response, where they degrade Ub-conjugated regulatory proteins.
- As part of the Ub system, they are involved in regulating the cell cycle.
- They are involved in cellular differentiation (where they degrade transcription factors and metabolic enzymes).
- They play an important role in the immune system by generating antigenic peptides that are presented by the major histocompatibility complex (MHC) class I molecules (such molecules are studied in Immunology).
why proteasomes are important?
proteasomes remove and brak down damaged or abnormal proteins that have been tagged with ubiquitin.
- proteasomes are organelles that contain an assortment of protein digesting enzymes, or proteases. cytoplasmic enzymes attach chains of ubiquitin, a molecular''tag'' to proteins destined for recycling. tagged proteins are quickly transported into the proteasome. once inside, they are rapidly disassembled into amino acids and small peptides, which can be released into the cytoplasm.
- proteasomes are responsible for removing and recycling damaged or denatured proteins, and for breaking down abnormal proteins, such as those produced within cells infected by viruses. they also play a key role in the immune response.